Discovery of potent and selective DP1 receptor antagonists in the azaindole series

Yves Leblanc; Patrick Roy; Claude Dufresne; Nicolas Lachance; Zhaoyin Wang; Gary O'Neill; Gillian Greig; Danielle Denis; Marie-Claude Mathieu; Deborah Slipetz; Nicole Sawyer; Nancy Tsou

doi:10.1016/j.bmcl.2009.03.010

Discovery of potent and selective DP1 receptor antagonists in the azaindole series

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2125-8. doi: 10.1016/j.bmcl.2009.03.010. Epub 2009 Mar 9.

Authors

Yves Leblanc¹, Patrick Roy, Claude Dufresne, Nicolas Lachance, Zhaoyin Wang, Gary O'Neill, Gillian Greig, Danielle Denis, Marie-Claude Mathieu, Deborah Slipetz, Nicole Sawyer, Nancy Tsou

Affiliation

¹ Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada. yves_leblanc@merck.com

PMID: 19307115
DOI: 10.1016/j.bmcl.2009.03.010

Abstract

Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.

Publication types

Comparative Study

MeSH terms

Humans
Indoles / chemical synthesis
Indoles / chemistry
Indoles / pharmacology
Prostaglandin Antagonists / chemical synthesis*
Prostaglandin Antagonists / pharmacology
Receptors, Prostaglandin / antagonists & inhibitors*
Receptors, Prostaglandin / physiology
Structure-Activity Relationship

Substances

Indoles
MK-0524
Prostaglandin Antagonists
Receptors, Prostaglandin
prostanoid D receptor 1, human